Target：ERMAP

Gene Name：ERMAP RD SC

Protein Name：Erythroid membrane-associated protein (hERMAP) (Radin blood group antigen) (Scianna blood group antigen)

Human Gene Id：114625

Human Swiss Prot No：Q96PL5

Mouse Swiss Prot No：Q9JLN5

Immunogen：Synthesized peptide derived from human protein . at AA range: 30-110

Specificity：ERMAP Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：52kD

Background： The protein encoded by this gene is a cell surface transmembrane protein that may act as an erythroid cell receptor, possibly as a mediator of cell adhesion. Polymorphisms in this gene are responsible for the Scianna/Radin blood group system. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

Function：developmental stage:Expressed in fetal liver blood cells (at protein level). Highly expressed in fetal liver.,function:Possible role as a cell-adhesion or receptor molecule of erythroid cells.,online information:Blood group antigen gene mutation database,polymorphism:ERMAP is responsible for the Scianna/Radin blood group system which comprises seven different antigens. The Sc1 and Sc2 antigens are resulting from a single variation in position 57; Arg-57 corresponds to the Sc2 antigen and Gly-57 to the Sc1 antigen. The Sc2 antigen is rare with an occurrence of less than 1% in the population while Sc1 is more frequent. Sc3 is not expressed by individuals homozygous for a null allele encoding a truncated protein lacking its extracellular part (Sc-3). The Sc4 antigen corresponding to the previously defined Radin blood group antigen (Rd) is due to a single variation in position 60; Ala-60 cor

Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Cytoplasm .

Expression：Expressed in erythroid-enriched bone marrow (at protein level). Highly expressed in bone marrow and to a lower extent in leukocytes, thymus, lymph node and spleen.