Target：eRF3a

Fields：mRNA surveillance pathway

Gene Name：GSPT1

Protein Name：Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

Human Gene Id：2935

Human Swiss Prot No：P15170

Mouse Gene Id：14852

Mouse Swiss Prot No：Q8R050

Immunogen：The antiserum was produced against synthesized peptide derived from human GSPT1. AA range:101-150

Specificity：eRF3a Polyclonal Antibody detects endogenous levels of eRF3a protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GSPT1;ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor subunit 3a;eRF3a;G1 to S phase transition protein 1 homolog

Observed Band(KD)：55kD

Background：function:Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth.,similarity:Belongs to the GTP-binding elongation factor family. ERF3 subfamily.,subunit:Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9.,

Function：function:Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth.,similarity:Belongs to the GTP-binding elongation factor family. ERF3 subfamily.,subunit:Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9.,

Subcellular Location：intracellular,cytosol,translation release factor complex,

Expression： Lung,Testis,