Target：NR4A2

Fields：Aldosterone synthesis and secretion;Parathyroid hormone synthesis, secretion and action

Gene Name：NR4A2 NOT NURR1 TINUR

Protein Name：Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor)

Human Gene Id：4929

Human Swiss Prot No：P43354

Mouse Swiss Prot No：Q06219

Rat Swiss Prot No：Q07917

Immunogen：Synthesized peptide derived from human protein . at AA range: 100-180

Specificity：NR4A2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：65kD

Background： This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008],

Function：developmental stage:Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle.,function:Probable nuclear receptor. May function as a general coactivator of gene transcription. Detection of the protein in the brain, indicates that it is not mandatorily associated with cell cycle progression.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR4 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,tissue specificity:Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.,

Subcellular Location：Cytoplasm. Nucleus. Mostly nuclear; oxidative stress promotes cytoplasmic localization.

Expression：Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.