Target：NPY1-R

Fields：cAMP signaling pathway;Neuroactive ligand-receptor interaction;Regulation of lipolysis in adipocytes

Gene Name：NPY1R

Protein Name：Neuropeptide Y receptor type 1

Human Gene Id：4886

Human Swiss Prot No：P25929

Mouse Gene Id：18166

Mouse Swiss Prot No：Q04573

Rat Swiss Prot No：P21555

Immunogen：The antiserum was produced against synthesized peptide derived from human NPY1R. AA range:221-270

Specificity：NPY1-R Polyclonal Antibody detects endogenous levels of NPY1-R protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NPY1R;NPYR;NPYY1;Neuropeptide Y receptor type 1;NPY1-R

Observed Band(KD)：48kD

Background： This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013],

Function：function:Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression： Blood,Brain,Pancreas,Testis,