Target：NPTX2

Gene Name：NPTX2

Protein Name：Neuronal pentraxin-2 (NP2) (Neuronal pentraxin II) (NP-II)

Human Gene Id：4885

Human Swiss Prot No：P47972

Mouse Swiss Prot No：O70340

Rat Swiss Prot No：P97738

Immunogen：Synthesized peptide derived from human protein . at AA range: 130-210

Specificity：NPTX2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：47kD

Background： This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009],

Function：cofactor:Binds 2 calcium ions per subunit.,function:Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner.,similarity:Contains 1 pentaxin domain.,tissue specificity:Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis.,

Subcellular Location：Secreted .

Expression：Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis.