Target：NPT2C

Fields：Parathyroid hormone synthesis, secretion and action;Mineral absorption

Gene Name：SLC34A3 NPT2C NPTIIC

Protein Name：Sodium-dependent phosphate transport protein 2C (Sodium-phosphate transport protein 2C) (Na(+)-dependent phosphate cotransporter 2C) (Sodium/inorganic phosphate cotransporter IIC) (Sodium/phosphate co

Human Gene Id：142680

Human Swiss Prot No：Q8N130

Mouse Swiss Prot No：Q80SU6

Rat Swiss Prot No：Q8K4R8

Immunogen：Synthesized peptide derived from human protein . at AA range: 250-330

Specificity：NPT2C Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：65kD

Background： This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.[provided by RefSeq, Apr 2010],

Function：disease:Defects in SLC34A3 are the cause of hereditary hypophosphatemic rickets with hypercalciuria (HHRH) [MIM:241530]. HHRH is an autosomal recessive form of hypophosphatemia characterized by reduced renal phosphate reabsorption and rickets. Increased serum levels of 1,25-dihydroxyvitamin D lead to increase in urinary calcium excretion.,function:May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.,miscellaneous:A 2:1 stoichiometry to Na(+)/Pi is observed at pH 7.4.,similarity:Belongs to the SLC34A transporter family.,

Subcellular Location：Membrane; Multi-pass membrane protein.

Expression： Kidney,