Target：NPT2A
Fields：Parathyroid hormone synthesis, secretion and action;Mineral absorption
Gene Name：SLC34A1 NPT2 SLC17A2
Protein Name：Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (NaPi-3) (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporte
Human Gene Id：6569
Human Swiss Prot No：Q06495
Mouse Swiss Prot No：Q60825
Rat Swiss Prot No：Q06496
Immunogen：Synthesized peptide derived from human protein . at AA range: 260-340
Specificity：NPT2A Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：70kD
Background： This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009],
Function：disease:Defects in SLC34A1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 1 (NPHLOP1) [MIM:612286]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).,function:May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.,similarity:Belongs to the SLC34A transporter family.,subunit:Interacts via its C-terminal region with PDZK2.,tissue specificity:Kidney and lung.,
Subcellular Location：Apical cell membrane ; Multi-pass membrane protein .
Expression：Kidney and lung.
