Target：NOSIP

Gene Name：NOSIP CGI-25

Protein Name：Nitric oxide synthase-interacting protein (eNOS-interacting protein)

Human Gene Id：51070

Human Swiss Prot No：Q9Y314

Mouse Swiss Prot No：Q9D6T0

Immunogen：Synthesized peptide derived from human protein . at AA range: 220-300

Specificity：NOSIP Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：33kD

Background： The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012],

Function：domain:The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not.,function:Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the NOSIP family.,subcellular location:Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle.,subunit:Interacts with NOS1 and NOS3.,tissue specificity:Expressed in heart, brain and lung. Present in endothelial cells (at protein level).,

Subcellular Location：Cytoplasm . Nucleus . Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813).

Expression：Expressed in heart, brain and lung. Present in endothelial cells (at protein level).