Target：Nop132

Gene Name：NOL8

Protein Name：Nucleolar protein 8

Human Gene Id：55035

Human Swiss Prot No：Q76FK4

Mouse Swiss Prot No：Q3UHX0

Immunogen：The antiserum was produced against synthesized peptide derived from human NOL8. AA range:1118-1167

Specificity：Nop132 Polyclonal Antibody detects endogenous levels of Nop132 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NOL8;C9orf34;NOP132;Nucleolar protein 8;Nucleolar protein Nop132

Observed Band(KD)：130kD

Background： NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008],

Function：function:Plays an essential role in the survival of diffuse-type gastric cancer cells. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.,induction:Up-regulated in diffuse-type gastric cancers.,PTM:Phosphorylated.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Interacts with the GTP form of RRAGA, RRAGC and RRAGD. Interacts with NIP7.,tissue specificity:Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle.,

Subcellular Location：Nucleus, nucleolus . Localizes in the nucleolar-organizing region during ribosome biogenesis.

Expression：Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle.