Target：NOG1

Fields：Ribosome biogenesis in eukaryotes

Gene Name：GTPBP4 CRFG NOG1

Protein Name：Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)

Human Gene Id：23560

Human Swiss Prot No：Q9BZE4

Mouse Swiss Prot No：Q99ME9

Rat Swiss Prot No：Q99P77

Immunogen：Synthesized peptide derived from human protein . at AA range: 580-660

Specificity：NOG1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：69kD

Background： GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008],

Function：function:Involved in the biogenesis of the 60S ribosomal subunit.,similarity:Belongs to the GTP1/OBG family. NOG subfamily.,

Subcellular Location：Nucleus, nucleolus .

Expression： Cervix carcinoma,Epithelium,Kidney,Liver,Uterus,