Target：GRIN2D

Fields：Calcium signaling pathway;cAMP signaling pathway;Neuroactive ligand-receptor interaction;Circadian entrainment;Long-term potentiation;Glutamatergic synapse;Alzheimer disease;Amyotrophic lateral sclerosis;Spinocerebellar ataxia;Prion disease;Pathways of neurodegeneration - multiple diseases;Cocaine addiction;Amphetamine addiction;Nicotine addiction;Alcoholism

Gene Name：GRIN2D

Protein Name：Glutamate [NMDA] receptor subunit epsilon-4

Human Gene Id：2906

Human Swiss Prot No：O15399

Mouse Gene Id：14814

Mouse Swiss Prot No：Q03391

Rat Gene Id：24412

Rat Swiss Prot No：Q62645

Immunogen：The antiserum was produced against synthesized peptide derived from human GRIN2D. AA range:671-720

Specificity：NMDAε4 Polyclonal Antibody detects endogenous levels of NMDAε4 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GRIN2D;GluN2D;NMDAR2D;Glutamate [NMDA] receptor subunit epsilon-4;EB11;N-methyl D-aspartate receptor subtype 2D;NMDAR2D;NR2D

Observed Band(KD)：170kD

Background： N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010],

Function：function:NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B).,

Subcellular Location：Cell membrane ; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Expression： Brain,Fetal brain,