Target：NLGN3

Fields：Cell adhesion molecules

Gene Name：NLGN3 KIAA1480 NL3

Protein Name：Neuroligin-3 (Gliotactin homolog)

Human Gene Id：54413

Human Swiss Prot No：Q9NZ94

Mouse Swiss Prot No：Q8BYM5

Rat Swiss Prot No：Q62889

Immunogen：Synthesized peptide derived from human protein . at AA range: 610-690

Specificity：NLGN3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：93kD

Background： This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009],

Function：disease:Defects in NLGN3 may be the cause of susceptibility to X-linked Asperger syndrome 1 (ASPGX1) [MIM:300494]. ASPGX1 is considered to be a form of childhood autism.,disease:Defects in NLGN3 may be the cause of susceptibility to X-linked autism 1 (AUTSX1) [MIM:300425]. AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age.,function:Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. May play a role in formation or maintenance of synaptic junctions. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.,sequence cauti

Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse . Detected at both glutamatergic and GABAergic synapses. .

Expression：Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.