Target：Nicalin
Gene Name：NCLN
Protein Name：Nicalin
Human Gene Id：56926
Human Swiss Prot No：Q969V3
Mouse Gene Id：103425
Mouse Swiss Prot No：Q8VCM8
Rat Gene Id：314648
Rat Swiss Prot No：Q5XIA1
Immunogen：The antiserum was produced against synthesized peptide derived from human NCLN. AA range:474-523
Specificity：Nicalin Polyclonal Antibody detects endogenous levels of Nicalin protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：NCLN;Nicalin;Nicastrin-like protein
Observed Band(KD)：63kD
Background：function:May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.,similarity:Belongs to the nicastrin family.,subunit:Interacts with NOMO2. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, it probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex.,tissue specificity:Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.,
Function：function:May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.,similarity:Belongs to the nicastrin family.,subunit:Interacts with NOMO2. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, it probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex.,tissue specificity:Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.,
Subcellular Location：Endoplasmic reticulum membrane ; Single-pass membrane protein .
Expression：Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.
