Target：NHE-8

Gene Name：SLC9A8

Protein Name：Sodium/hydrogen exchanger 8

Human Gene Id：23315

Human Swiss Prot No：Q9Y2E8

Mouse Gene Id：77031

Mouse Swiss Prot No：Q8R4D1

Rat Gene Id：311651

Rat Swiss Prot No：Q4L208

Immunogen：The antiserum was produced against synthesized peptide derived from human SLC9A8. AA range:451-500

Specificity：NHE-8 Polyclonal Antibody detects endogenous levels of NHE-8 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000.IHC:1:50-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SLC9A8;KIAA0939;NHE8;Sodium/hydrogen exchanger 8;Na(+)/H(+) exchanger 8;NHE-8;Solute carrier family 9 member 8

Observed Band(KD)：65kD

Background： Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009],

Function：function:Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.,similarity:Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.,tissue specificity:Ubiquitous. Strongly expressed in skeletal muscle and kidney.,

Subcellular Location：Golgi apparatus membrane ; Multi-pass membrane protein .

Expression：Ubiquitous. Strongly expressed in skeletal muscle and kidney.