Target：NF-L

Fields：Amyotrophic lateral sclerosis;Pathways of neurodegeneration - multiple diseases

Gene Name：NEFL

Protein Name：Neurofilament light polypeptide

Human Gene Id：4747

Human Swiss Prot No：P07196

Mouse Gene Id：18039

Mouse Swiss Prot No：P08551

Rat Gene Id：83613

Rat Swiss Prot No：P19527

Immunogen：Synthesized peptide derived from the C-terminal region of human NF-L.

Specificity：NF-L Polyclonal Antibody detects endogenous levels of NF-L protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NEFL;NF68;NFL;Neurofilament light polypeptide;NF-L;68 kDa neurofilament protein;Neurofilament triplet L protein

Observed Band(KD)：61kD

Background： Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008],

Function：caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 1F (CMT1F) [MIM:607734]. CMT1F is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1F is charac

Subcellular Location：Cell projection, axon . Cytoplasm, cytoskeleton .

Expression： Amygdala,Brain,Fetal brain cortex,Thalamus,