Target：NETO1

Gene Name：NETO1 BTCL1

Protein Name：Neuropilin and tolloid-like protein 1 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1)

Human Gene Id：81832

Human Swiss Prot No：Q8TDF5

Mouse Swiss Prot No：Q8R4I7

Immunogen：Synthesized peptide derived from human protein . at AA range: 20-100

Specificity：NETO1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：58kD

Background： This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],

Function：function:May play a role in the development and/or maintenance of neuronal circuitry.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 2 CUB domains.,tissue specificity:Isoform 1 and isoform 2 are retina-specific whereas isoform 3 is found in retina as well as at lower levels in adult and fetal brain.,

Subcellular Location：[Isoform 2]: Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse, postsynaptic density membrane . Component of the postsynaptic density (PSD) of excitatory synapses. .; [Isoform 3]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 1]: Secreted .

Expression：Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain.