Target：NEDL2

Gene Name：HECW2

Protein Name：E3 ubiquitin-protein ligase HECW2

Human Gene Id：57520

Human Swiss Prot No：Q9P2P5

Mouse Swiss Prot No：Q6I6G8

Immunogen：The antiserum was produced against synthesized peptide derived from human HECW2. AA range:481-530

Specificity：NEDL2 Polyclonal Antibody detects endogenous levels of NEDL2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：HECW2;KIAA1301;NEDL2;E3 ubiquitin-protein ligase HECW2;HECT; C2 and WW domain-containing protein 2;NEDD4-like E3 ubiquitin-protein ligase 2

Observed Band(KD)：140-150kD

Background：function:E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with TP73.,tissue specificity:Predominantly expressed in adult brain, lung and heart.,

Function：function:E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with TP73.,tissue specificity:Predominantly expressed in adult brain, lung and heart.,

Subcellular Location：Cytoplasm . Cytoplasm, cytoskeleton, spindle .

Expression：Predominantly expressed in adult brain, lung and heart.