Target：NDUFA8

Fields：Oxidative phosphorylation;Metabolic pathways;Thermogenesis;Retrograde endocannabinoid signaling;Non-alcoholic fatty liver disease;Alzheimer disease;Parkinson disease;Amyotrophic lateral sclerosis;Huntington disease;Prion disease;Pathways of neurodegeneration - multiple diseases;Chemical carcinogenesis - reactive oxygen species;Diabetic cardiomyopathy

Gene Name：NDUFA8

Protein Name：NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

Human Gene Id：4702

Human Swiss Prot No：P51970

Mouse Gene Id：68375

Mouse Swiss Prot No：Q9DCJ5

Immunogen：The antiserum was produced against synthesized peptide derived from human NDUFA8. AA range:109-158

Specificity：NDUFA8 Polyclonal Antibody detects endogenous levels of NDUFA8 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NDUFA8;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8;Complex I-19kD;CI-19kD;Complex I-PGIV;CI-PGIV;NADH-ubiquinone oxidoreductase 19 kDa subunit

Observed Band(KD)：22kD

Background： The protein encoded by this gene belongs to the complex I 19 kDa subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015],

Function：function:Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.,similarity:Belongs to the complex I NDUFA8 subunit family.,similarity:Contains 2 CHCH domains.,subunit:Complex I is composed of 45 different subunits.,

Subcellular Location：Mitochondrion inner membrane ; Peripheral membrane protein . Mitochondrion intermembrane space . Mitochondrion .

Expression： Kidney,Lymph,Thalamus,