Target：Ndfip1

Gene Name：NDFIP1

Protein Name：NEDD4 family-interacting protein 1

Human Gene Id：80762

Human Swiss Prot No：Q9BT67

Mouse Gene Id：65113

Mouse Swiss Prot No：Q8R0W6

Rat Gene Id：291609

Rat Swiss Prot No：Q5U2S1

Immunogen：Synthesized peptide derived from Ndfip1 . at AA range: 150-230

Specificity：Ndfip1 Polyclonal Antibody detects endogenous levels of Ndfip1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NDFIP1;N4WBP5;PSEC0192;PSEC0223;NEDD4 family-interacting protein 1;Breast cancer-associated protein SGA-1M;NEDD4 WW domain-binding protein 5;Putative MAPK-activating protein PM13;Putative NF-kappa-B-activating protein 164;Putative

Observed Band(KD)：25kD

Background： The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008],

Function：developmental stage:Expressed in fetal brain, kidney and lung.,domain:The WW-binding motifs mediate interaction with NEDD4.,function:May play a role in Golgi structure maintenance.,PTM:Ubiquitinated by NEDD4; mono-, di- and polyubiquitinated forms are detected. Ubiquitination regulates its degradation.,subunit:Interacts with NEDD4. Interacts in vitro with NEDD4L, SR140, WWP2 and ITCH.,tissue specificity:Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta.,

Subcellular Location：Endosome membrane ; Multi-pass membrane protein . Golgi apparatus membrane . Cell junction, synapse, synaptosome . Cell projection, dendrite . Secreted . Detected in exosomes and secreted via the exosomal pathway (PubMed:18819914).

Expression：Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung.