Target：Adenosine A1-R

Fields：cGMP-PKG signaling pathway;cAMP signaling pathway;Sphingolipid signaling pathway;Neuroactive ligand-receptor interaction;Regulation of lipolysis in adipocytes;Renin secretion;Morphine addiction

Gene Name：ADORA1

Protein Name：Adenosine receptor A1

Human Gene Id：134

Human Swiss Prot No：P30542

Mouse Swiss Prot No：Q60612

Rat Gene Id：29290

Rat Swiss Prot No：P25099

Immunogen：The antiserum was produced against synthesized peptide derived from human ADORA1. AA range:277-326

Specificity：Adenosine A1-R Polyclonal Antibody detects endogenous levels of Adenosine A1-R protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ADORA1;Adenosine receptor A1

Observed Band(KD)：37kD

Background： The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008],

Function：function:Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein.

Expression： Brain,Heart,Hippocampus,