Target：ADCY3
Fields：Purine metabolism;Metabolic pathways;Endocrine resistance;Rap1 signaling pathway;Calcium signaling pathway;cGMP-PKG signaling pathway;cAMP signaling pathway;Chemokine signaling pathway;Phospholipase D signaling pathway;Oocyte meiosis;Longevity regulating pathway;Longevity regulating pathway - multiple species;Adrenergic signaling in cardiomyocytes;Vascular smooth muscle contraction;Apelin signaling pathway;Gap junction;Platelet activation;Circadian entrainment;Thermogenesis;Retrograde endocannabinoid signaling;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Olfactory transduction;Inflammatory mediator regulation of TRP channels;Insulin secretion;GnRH signaling pathway;Ovarian steroidogenesis;Progesterone-mediated oocyte maturation;Estrogen signaling pathway;Melanogenesis;Thyroid hormone synthesis;Oxytocin signaling pathway;Regulation of lipolysis in adipocytes;Aldosterone synthesis and secretion;Relaxin
Gene Name：ADCY3 KIAA0511
Protein Name：Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3)
Human Gene Id：109
Human Swiss Prot No：O60266
Mouse Swiss Prot No：Q8VHH7
Rat Swiss Prot No：P21932
Immunogen：Synthesized peptide derived from human protein . at AA range: 950-1030
Specificity：ADCY3 Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：125kD
Background： This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016],
Function：catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Activated by calcium/calmodulin.,function:Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,tissue specificity:Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.,
Subcellular Location：Cell membrane ; Multi-pass membrane protein . Cytoplasm . Cell projection, cilium . Golgi apparatus . Also detected in the cytoplasm, close to lipid droplets. .
Expression：Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle (PubMed:9920776). Detected in testis (PubMed:15705663).
