Target：NANO2

Gene Name：NANOS2 NOS2

Protein Name：Nanos homolog 2 (NOS-2)

Human Gene Id：339345

Human Swiss Prot No：P60321

Mouse Swiss Prot No：P60322

Immunogen：Synthesized peptide derived from human protein . at AA range: 10-90

Specificity：NANO2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：15kD

Background：domain:The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.,function:Required to support proliferation and self-renewal of proximal germ cells in males only. Probably regulates translation of specific mRNAs by associating with the 3'-UTR of mRNA targets. Essential for spermatogonia formation.,similarity:Belongs to the nanos family.,similarity:Contains 1 nanos-type zinc finger.,

Function：domain:The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.,function:Required to support proliferation and self-renewal of proximal germ cells in males only. Probably regulates translation of specific mRNAs by associating with the 3'-UTR of mRNA targets. Essential for spermatogonia formation.,similarity:Belongs to the nanos family.,similarity:Contains 1 nanos-type zinc finger.,

Subcellular Location：Cytoplasm . Cytoplasm, P-body . Cytoplasm, perinuclear region . Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. .

Expression：Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level).