Target：NAB2

Gene Name：NAB2

Protein Name：NGFI-A-binding protein 2

Human Gene Id：4665

Human Swiss Prot No：Q15742

Mouse Gene Id：17937

Mouse Swiss Prot No：Q61127

Immunogen：The antiserum was produced against synthesized peptide derived from human NAB2. AA range:261-310

Specificity：NAB2 Polyclonal Antibody detects endogenous levels of NAB2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NAB2;MADER;NGFI-A-binding protein 2;EGR-1-binding protein 2;Melanoma-associated delayed early response protein;Protein MADER

Observed Band(KD)：56kD

Background： This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008],

Function：domain:The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.,domain:The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.,function:Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.,induction:By serum and PMA stimulation.,similarity:Belongs to the NAB family.,subcellular location:Isoform 2 is not localized to the nucleus.,subunit:Homomultimers may associate with EGR1 bound to DNA.,tissue specificity:Widely expressed at low levels. Highly expressed in melanoma cell lines.,

Subcellular Location：Nucleus . Isoform 2 is not localized to the nucleus. .

Expression：Widely expressed at low levels. Highly expressed in melanoma cell lines.