Target：MLKL
Fields：Necroptosis;TNF signaling pathway;Salmonella infection
Gene Name：MLKL
Protein Name：Mixed lineage kinase domain-like protein
Human Gene Id：197259
Human Swiss Prot No：Q8NB16
Mouse Swiss Prot No：Q9D2Y4
Immunogen：Synthesized peptide derived from MLKL . at AA range: 40-120
Specificity：MLKL Polyclonal Antibody detects endogenous levels of MLKL protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000;IHC 1:50-300
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：MLKL;Mixed lineage kinase domain-like protein
Observed Band(KD)：55kD
Background： This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
Function：domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,
Subcellular Location：Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .
Expression： Chondrocyte,Leukocyte,Lymph node,
