Target:MK04
Fields:IL-17 signaling pathway
Gene Name:MAPK4 ERK4 PRKM4
Protein Name:Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK)
Human Gene Id:5596
Human Swiss Prot No:P31152
Mouse Swiss Prot No:Q6P5G0
Rat Swiss Prot No:Q63454
Immunogen:Synthesized peptide derived from human protein . at AA range: 410-490
Specificity:MK04 Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):64kD
Background: Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
Function:catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:High expression in heart and brain.,
Subcellular Location:Cytoplasm . Nucleus . Translocates to the cytoplasm following interaction with MAPKAPK5. .
Expression:High expression in heart and brain.