Target：MIS

Fields：cAMP signaling pathway;Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Hippo signaling pathway

Gene Name：AMH MIF

Protein Name：Muellerian-inhibiting factor (Anti-Muellerian hormone) (AMH) (Muellerian-inhibiting substance) (MIS)

Human Gene Id：268

Human Swiss Prot No：P03971

Mouse Swiss Prot No：P27106

Rat Swiss Prot No：P49000

Immunogen：Synthesized peptide derived from human protein . at AA range: 380-460

Specificity：MIS Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：61kD

Background： This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016],

Function：disease:Defects in AMH are the cause of persistent Muellerian duct syndrome type 1 (PMDS-1) [MIM:261550]. PMDS-1 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.,function:This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.,miscellaneous:Although it does not compete with EGF for receptor binding sites, MIS can inhibit the autophosphorylation of the EGF receptor in vitro.,online information:Anti-Mullerian hormone entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,

Subcellular Location：Secreted .

Expression：In ovaries, AMH is detected in granulosa cells of early growing follicles.