Target：MIPP

Fields：Glycolysis / Gluconeogenesis;Inositol phosphate metabolism;Metabolic pathways

Gene Name：MINPP1

Protein Name：Multiple inositol polyphosphate phosphatase 1

Human Gene Id：9562

Human Swiss Prot No：Q9UNW1

Mouse Gene Id：17330

Mouse Swiss Prot No：Q9Z2L6

Rat Gene Id：29688

Rat Swiss Prot No：O35217

Immunogen：The antiserum was produced against synthesized peptide derived from human MINPP1. AA range:328-377

Specificity：MIPP Polyclonal Antibody detects endogenous levels of MIPP protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MINPP1;MIPP;Multiple inositol polyphosphate phosphatase 1;2;3-bisphosphoglycerate 3-phosphatase;2,3-BPG phosphatase;Inositol;1,3,4,5)-tetrakisphosphate 3-phosphatase;Ins(1,3,4,5)P(4) 3-phosphatase

Observed Band(KD)：60kD

Background： This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009],

Function：catalytic activity:Myo-inositol hexakisphosphate + H(2)O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.,disease:Defects in MINPP1 may be involved in follicular thyroid tumors development.,function:Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (By similarity). May play a role in bone development (endochondral ossification).,tissue specificity:Widely expressed with highest levels in kidney, liver and placenta.,

Subcellular Location：Endoplasmic reticulum lumen .

Expression：Widely expressed with highest levels in kidney, liver and placenta.