Target：MGST3

Fields：Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Platinum drug resistance;Pathways in cancer;Chemical carcinogenesis - DNA adducts;Chemical carcinogenesis - receptor activation;Chemical carcinogenesis - reactive oxygen species;Hepatocellular carcinoma;Fluid shear stress and atherosclerosis

Gene Name：MGST3

Protein Name：Microsomal glutathione S-transferase 3

Human Gene Id：4259

Human Swiss Prot No：O14880

Mouse Gene Id：66447

Mouse Swiss Prot No：Q9CPU4

Immunogen：The antiserum was produced against synthesized peptide derived from human MGST3. AA range:8-57

Specificity：MGST3 Polyclonal Antibody detects endogenous levels of MGST3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MGST3;Microsomal glutathione S-transferase 3;Microsomal GST-3;Microsomal GST-III

Molecular Weight(Da)：17kD

Background： This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011],

Function：catalytic activity:RX + glutathione = HX + R-S-glutathione.,function:Also functions as a glutathione peroxidase.,similarity:Belongs to the MAPEG family.,tissue specificity:Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.,

Subcellular Location：Endoplasmic reticulum membrane ; Multi-pass membrane protein . Microsome membrane ; Multi-pass membrane protein . Microsome membrane ; Lipid-anchor . Membrane .

Expression：Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.