Target:MGRN1
Fields:Ubiquitin mediated proteolysis;Hedgehog signaling pathway
Gene Name:MGRN1 KIAA0544 RNF156
Protein Name:E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin RING finger protein 1) (RING finger protein 156)
Human Gene Id:23295
Human Swiss Prot No:O60291
Mouse Swiss Prot No:Q9D074
Rat Swiss Prot No:Q5XIQ4
Immunogen:Synthesized peptide derived from part region of human protein
Specificity:MGRN1 Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):60kD
Background: Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004],
Function:domain:The RING finger is required for ubiquitin ligase activity.,function:Probable E3 ubiquitin-protein ligase.,pathway:Protein modification; protein ubiquitination.,PTM:Autoubiquitinated in vitro.,similarity:Contains 1 RING-type zinc finger.,
Subcellular Location:Early endosome . The endosomal localization is dependent on the interaction with TSG101.; [Isoform 1]: Cytoplasm, cytosol. Nucleus. Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.; [Isoform 2]: Cytoplasm, cytosol. Nucleus. Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.; [Isoform 3]: Cytoplasm, cytosol. Cell membrane.; [Isoform 4]: Cytoplasm, cytosol. Cell membrane.
Expression: Brain,Leukocyte,