Target：mGluR5

Fields：Calcium signaling pathway;Phospholipase D signaling pathway;Neuroactive ligand-receptor interaction;Gap junction;Long-term potentiation;Retrograde endocannabinoid signaling;Glutamatergic synapse;Alzheimer disease;Huntington disease;Pathways of neurodegeneration - multiple diseases

Gene Name：GRM5

Protein Name：Metabotropic glutamate receptor 5

Human Gene Id：2915

Human Swiss Prot No：P41594

Mouse Gene Id：108071

Mouse Swiss Prot No：Q3UVX5

Rat Gene Id：24418

Rat Swiss Prot No：P31424

Immunogen：The antiserum was produced against synthesized peptide derived from human GRM5. AA range:21-70

Specificity：mGluR5 Polyclonal Antibody detects endogenous levels of mGluR5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GRM5;GPRC1E;MGLUR5;Metabotropic glutamate receptor 5;mGluR5

Observed Band(KD)：130kD

Background：glutamate metabotropic receptor 5(GRM5) Homo sapiens This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],

Function：function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression： Brain,