Target：MEP1B

Fields：Protein digestion and absorption

Gene Name：MEP1B

Protein Name：Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta) (PABA peptide hydrolase) (PPH beta)

Human Gene Id：4225

Human Swiss Prot No：Q16820

Mouse Swiss Prot No：Q61847

Rat Swiss Prot No：P28826

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：MEP1B Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：77kD

Background： Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011],

Function：catalytic activity:Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.,cofactor:Binds 1 zinc ion per subunit.,similarity:Belongs to the peptidase M12A family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 MAM domain.,similarity:Contains 1 MATH domain.,subunit:Homotetramer of alpha or beta subunits; heterotetramer of two alpha and two beta subunits are formed by non-covalent association of two disulfide-linked heterodimers.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein. Secreted . Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17. .

Expression：The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells.