Target：PLCB1

Fields：Inositol phosphate metabolism;Metabolic pathways;Rap1 signaling pathway;Calcium signaling pathway;cGMP-PKG signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;Sphingolipid signaling pathway;Phospholipase D signaling pathway;Adrenergic signaling in cardiomyocytes;Vascular smooth muscle contraction;Wnt signaling pathway;Apelin signaling pathway;Gap junction;Platelet activation;Neutrophil extracellular trap formation;NOD-like receptor signaling pathway;Circadian entrainment;Long-term potentiation;Retrograde endocannabinoid signaling;Glutamatergic synapse;Cholinergic synapse;Serotonergic synapse;Dopaminergic synapse;Long-term depression;Taste transduction;Inflammatory mediator regulation of TRP channels;Insulin secretion;GnRH signaling pathway;Estrogen signaling pathway;Melanogenesis;Thyroid hormone synthesis;Thyroid hormone signaling pathway;Oxytocin signaling pathway;Glucagon signaling p

Gene Name：PLCB1 KIAA0581

Protein Name：1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)

Human Gene Id：23236

Human Swiss Prot No：Q9NQ66

Mouse Swiss Prot No：Q9Z1B3

Rat Swiss Prot No：P10687

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：PLCB1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：133kD

Background： The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function：catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.,miscellaneous:The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,

Subcellular Location：Nucleus membrane . Cytoplasm . Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. .

Expression： Brain,Epithelium,Placenta,Testis,