Target：OCT3

Fields：Choline metabolism in cancer

Gene Name：SLC22A3

Protein Name：Solute carrier family 22 member 3

Human Gene Id：6581

Human Swiss Prot No：O75751

Mouse Swiss Prot No：Q9WTW5

Immunogen：The antiserum was produced against synthesized peptide derived from human SLC22A3. AA range:275-324

Specificity：OCT3 Polyclonal Antibody detects endogenous levels of 40819 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SLC22A3;EMTH;OCT3;Solute carrier family 22 member 3;Extraneuronal monoamine transporter;EMT;Organic cation transporter 3

Observed Band(KD)：61kD

Background： Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008],

Function：function:Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.,similarity:Belongs to the major facilitator superfamily. Organic cation transporter family.,tissue specificity:Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.,

Subcellular Location：Membrane; Multi-pass membrane protein.

Expression：Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.