Target:OAS2
Fields:NOD-like receptor signaling pathway;Hepatitis C;Measles;Influenza A;Herpes simplex virus 1 infection;Epstein-Barr virus infection;Coronavirus disease - COVID-19
Gene Name:OAS2
Protein Name:2'-5'-oligoadenylate synthase 2
Human Gene Id:4939
Human Swiss Prot No:P29728
Mouse Gene Id:246728
Mouse Swiss Prot No:E9Q9A9
Rat Gene Id:363938
Rat Swiss Prot No:Q5MYU0
Immunogen:The antiserum was produced against synthesized peptide derived from the N-terminal region of human OAS2. AA range:61-110
Specificity:OAS2 Polyclonal Antibody detects endogenous levels of OAS2 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:OAS2;2'-5'-oligoadenylate synthase 2;(2-5')oligo(A) synthase 2;2-5A synthase 2;p69 OAS / p71 OAS;p69OAS / p71OAS
Observed Band(KD):82kD
Background:2'-5'-oligoadenylate synthetase 2(OAS2) Homo sapiens This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
Function:catalytic activity:Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs.,function:May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.,induction:By interferons.,similarity:Belongs to the 2-5A synthetase family.,subcellular location:Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.,subunit:Homodimer.,
Subcellular Location:Cytoplasm . Cytoplasm, perinuclear region .
Expression: Blood,Colon,Testis,Uterus,