Target：NRX3A

Gene Name：NRXN3 C14orf60 KIAA0743

Protein Name：Neurexin-3-alpha (Neurexin III-alpha)

Human Gene Id：9369

Human Swiss Prot No：Q9Y4C0

Mouse Swiss Prot No：Q6P9K9

Rat Swiss Prot No：Q07310

Immunogen：Synthesized peptide derived from human protein . at AA range: 480-560

Specificity：NRX3A Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：180kD

Background：alternative products:A number of isoforms, alpha-type (AC Q9Y4C0) and beta-type (shown here), are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus,alternative products:A number of isoforms, alpha-type (shown here) and beta-type (AC Q9HDB5), are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. Additional isoforms produced by alternative splicing seem to exist,function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.,function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.,similarity:Belongs to the neurexin family.,similarity:Contains 1 laminin G-like domain.,similarity:Contains 3 EGF-like domains.,similarity:Contains 6 laminin G-like domains.,subunit:The cytoplasmic C-terminal region binds to CASK (By similarity). Binds to neuroligins NLGN1, NLGN2 and NLGN3.,subunit:The laminin G-like domain 2 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. The cytoplasmic C-terminal region binds to CASK.,tissue specificity:Predominantly expressed in brain.,

Function：alternative products:A number of isoforms, alpha-type (AC Q9Y4C0) and beta-type (shown here), are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus,alternative products:A number of isoforms, alpha-type (shown here) and beta-type (AC Q9HDB5), are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. Additional isoforms produced by alternative splicing seem to exist,function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.,function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.,similarity:Belongs to the neurexin family.,similarity:Contains 1 laminin G-like domain.,similarity:Contains 3 EGF-like domains.,similarity:Contains 6 laminin G-like domains.,subun

Subcellular Location：Membrane ; Single-pass type I membrane protein .

Expression：Expressed in the blood vessel walls (at protein level). Highly expressed in brain, lung, and pancreas; a lower level of expression is detectable in heart, placenta, liver, and kidney, whereas no expression can be observed in skeletal muscle. Isoform 4a is heart-specific.