Target:NRBF-2
Fields:Autophagy - animal;Alzheimer disease;Amyotrophic lateral sclerosis;Huntington disease;Spinocerebellar ataxia;Pathways of neurodegeneration - multiple diseases
Gene Name:NRBF2
Protein Name:Nuclear receptor-binding factor 2
Human Gene Id:29982
Human Swiss Prot No:Q96F24
Mouse Gene Id:641340
Mouse Swiss Prot No:Q8VCQ3
Rat Gene Id:58839
Rat Swiss Prot No:Q9QYK3
Immunogen:The antiserum was produced against synthesized peptide derived from human NRBF2. AA range:140-189
Specificity:NRBF-2 Polyclonal Antibody detects endogenous levels of NRBF-2 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:NRBF2;COPR;Nuclear receptor-binding factor 2;NRBF-2;Comodulator of PPAR and RXR
Observed Band(KD):36kD
Background:function:May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).,subunit:Interacts with PPARA, PPARD and PPARG. Interacts with RARA, RARG and RXRA in the presence of bound ligand.,tissue specificity:Detected in keratinocytes, liver and placenta.,
Function:function:May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).,subunit:Interacts with PPARA, PPARD and PPARG. Interacts with RARA, RARG and RXRA in the presence of bound ligand.,tissue specificity:Detected in keratinocytes, liver and placenta.,
Subcellular Location:Nucleus . Cytoplasm . Cytoplasmic vesicle . Cytoplasmic vesicle, autophagosome .
Expression:Detected in keratinocytes, liver and placenta (PubMed:15610520). Expressed in a subset of cells in pediatric medulloblastoma (PubMed:18619852).