Target:OXSR1
Gene Name:OXSR1
Protein Name:Serine/threonine-protein kinase OSR1
Human Gene Id:9943
Human Swiss Prot No:O95747
Mouse Gene Id:108737
Mouse Swiss Prot No:Q6P9R2
Immunogen:The antiserum was produced against synthesized peptide derived from human OXSR1. AA range:272-321
Specificity:OXSR1 Polyclonal Antibody detects endogenous levels of OXSR1 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:OXSR1;KIAA1101;OSR1;Serine/threonine-protein kinase OSR1;Oxidative stress-responsive 1 protein
Observed Band(KD):50kD
Background: The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008],
Function:catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:By autophosphorylation on threonine.,function:Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT.,tissue specificity:Ubiquitously expressed in all tissue examined.,
Subcellular Location:Cytoplasm .
Expression:Ubiquitously expressed in all tissue examined.