Target：Ox40L

Fields：Cytokine-cytokine receptor interaction

Gene Name：TNFSF4

Protein Name：Tumor necrosis factor ligand superfamily member 4

Human Gene Id：7292

Human Swiss Prot No：P23510

Mouse Gene Id：22164

Mouse Swiss Prot No：P43488

Rat Gene Id：89814

Rat Swiss Prot No：Q9Z2P3

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human TNFSF4. AA range:31-80

Specificity：Ox40L Polyclonal Antibody detects endogenous levels of Ox40L protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. IF 1:100-1:300. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TNFSF4;TXGP1;Tumor necrosis factor ligand superfamily member 4;Glycoprotein Gp34;OX40 ligand;OX40L;TAX transcriptionally-activated glycoprotein 1;CD252

Observed Band(KD)：21kD

Background： This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Function：disease:Genetic variation in TNFSF4 influences susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.,induction:By human T-cell leukemia virus type I transactivator P40-TAX.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,

Subcellular Location：Membrane; Single-pass type II membrane protein.

Expression： Testis,