Target：OSTCN

Fields：Parathyroid hormone synthesis, secretion and action

Gene Name：BGLAP

Protein Name：Osteocalcin (Bone Gla protein) (BGP) (Gamma-carboxyglutamic acid-containing protein)

Human Gene Id：632

Human Swiss Prot No：P02818

Mouse Swiss Prot No：P86546

Rat Swiss Prot No：P04640

Immunogen：Synthesized peptide derived from part region of human protein AA range: 31-80

Specificity：OSTCN Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：11kD

Background： This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015],

Function：function:Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.,function:Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.,induction:By polyamine analogs in analog-sensitive H157 cells.,online information:Osteocalcin entry,PTM:Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.,similarity:Belongs to the osteocalcin/matrix Gla protein family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,subcellular location:Associated with the kinetochore.,subunit:Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Interacts with COPS7A. Interacts via its coiled-

Subcellular Location：Secreted.

Expression： Brain,Cerebellum,Colon,Lung carcinoma,Skin,Testis,Uterus,