Target：OSCAR

Fields：Osteoclast differentiation

Gene Name：OSCAR

Protein Name：Osteoclast-associated immunoglobulin-like receptor (Osteoclast-associated receptor) (hOSCAR) (Polymeric immunoglobulin receptor 3) (PIgR-3) (PIgR3) (Poly-Ig receptor 3)

Human Gene Id：126014

Human Swiss Prot No：Q8IYS5

Mouse Swiss Prot No：Q8VBT3

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：OSCAR Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：31kD

Background： Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013],

Function：caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.,similarity:Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family.,similarity:Contains 2 Ig-like (immunoglobulin-like) domains.,

Subcellular Location：[Isoform 1]: Secreted .; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein .

Expression： Testis,