Target：Ribosomal Protein L11

Fields：Ribosome;Coronavirus disease - COVID-19

Gene Name：RPL11

Protein Name：60S ribosomal protein L11

Human Gene Id：6135

Human Swiss Prot No：P62913

Mouse Gene Id：67025

Mouse Swiss Prot No：Q9CXW4

Rat Swiss Prot No：P62914

Immunogen：Synthesized peptide derived from Ribosomal Protein L11 . at AA range: 100-180

Specificity：Ribosomal Protein L11 Polyclonal Antibody detects endogenous levels of Ribosomal Protein L11 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RPL11;60S ribosomal protein L11;CLL-associated antigen KW-12

Observed Band(KD)：20kD

Background： Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010],

Function：disease:Defects in RPL11 are the cause of Diamond-Blackfan anemia type 7 (DBA7) [MIM:612562]. DBA7 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.,function:Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits.,similarity:Belongs to the ribosomal protein L5P family.,

Subcellular Location：Nucleus, nucleolus . Cytoplasm .

Expression： Amygdala,Cervix carcinoma,Tonsil,