Target:PACAP
Gene Name:PACAP HSPC190
Protein Name:Plasma cell-induced resident endoplasmic reticulum protein (Plasma cell-induced resident ER protein) (pERp1) (Proapoptotic caspase adapter protein)
Human Gene Id:51237
Human Swiss Prot No:Q8WU39
Mouse Gene Id:69816
Mouse Swiss Prot No:Q9D8I1
Immunogen:Synthetic peptide from human protein at AA range: 1-50
Specificity:The antibody detects endogenous PACAP
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:Plasma cell-induced resident endoplasmic reticulum protein (Plasma cell-induced resident ER protein;pERp1;Proapoptotic caspase adapter protein)
Background:function:May be involved in regulation of apoptosis.,induction:Down-regulated in primary B-cells early after ligand-stimulated activation.,subcellular location:In (PubMed:11350957) diffuse granular localization in the cytoplasm surrounding the nucleus.,subunit:Isoform 2 interacts with CASP2 and CASP9.,tissue specificity:Widely expressed with highest levels in adult brain. Expression is frequently lower in intestinal-type gastric cancer.,
Function:function:May be involved in regulation of apoptosis.,induction:Down-regulated in primary B-cells early after ligand-stimulated activation.,subcellular location:In (PubMed:11350957) diffuse granular localization in the cytoplasm surrounding the nucleus.,subunit:Isoform 2 interacts with CASP2 and CASP9.,tissue specificity:Widely expressed with highest levels in adult brain. Expression is frequently lower in intestinal-type gastric cancer.,
Subcellular Location:[Isoform 1]: Endoplasmic reticulum lumen . Secreted .; [Isoform 2]: Cytoplasm . Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957).
Expression:Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat.