Target：Pax-8

Fields：Thyroid hormone synthesis;Pathways in cancer;Transcriptional misregulation in cancer;Thyroid cancer

Gene Name：PAX8

Protein Name：Paired box protein Pax-8

Human Gene Id：7849

Human Swiss Prot No：Q06710

Mouse Gene Id：18510

Mouse Swiss Prot No：Q00288

Rat Gene Id：81819

Rat Swiss Prot No：P51974

Immunogen：The antiserum was produced against synthesized peptide derived from human Pax-8. AA range:145-194

Specificity：Pax-8 Polyclonal Antibody detects endogenous levels of Pax-8 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PAX8;Paired box protein Pax-8

Observed Band(KD)：62kD

Background： This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010],

Function：caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,developmental stage:In developing excretory system, during thyroid differentiation and in adult thyroid.,disease:Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.,function:Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cell

Subcellular Location：Nucleus.

Expression：Expressed in the excretory system, thyroid gland and Wilms tumors.