Target：PAR-6β

Fields：Rap1 signaling pathway;Endocytosis;Axon guidance;Hippo signaling pathway;Tight junction;Human papillomavirus infection

Gene Name：PARD6B

Protein Name：Partitioning defective 6 homolog beta

Human Gene Id：84612

Human Swiss Prot No：Q9BYG5

Mouse Gene Id：58220

Mouse Swiss Prot No：Q9JK83

Immunogen：The antiserum was produced against synthesized peptide derived from human PARD6B. AA range:233-282

Specificity：PAR-6β Polyclonal Antibody detects endogenous levels of PAR-6β protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PARD6B;PAR6B;Partitioning defective 6 homolog beta;PAR-6 beta;PAR-6B

Observed Band(KD)：38kD

Background： This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008],

Function：domain:The PDZ domain mediates interaction with MPP5.,domain:The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.,function:Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.,similarity:Belongs to the PAR6 family.,similarity:Contains 1 OPR domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 pseudo-CRIB domain.,subunit:Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and

Subcellular Location：Cytoplasm. Cell membrane . Cell junction, tight junction .

Expression：Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.