Target：PAR1

Fields：Rap1 signaling pathway;Calcium signaling pathway;cAMP signaling pathway;Phospholipase D signaling pathway;Neuroactive ligand-receptor interaction;PI3K-Akt signaling pathway;Complement and coagulation cascades;Platelet activation;Regulation of actin cytoskeleton;Pathogenic Escherichia coli infection;Pathways in cancer

Gene Name：F2R CF2R PAR1 TR

Protein Name：Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)

Human Gene Id：2149

Human Swiss Prot No：P25116

Mouse Gene Id：14062

Mouse Swiss Prot No：P30558

Rat Swiss Prot No：P26824

Immunogen：Synthesized peptide derived from human PAR1 (Cleaved-Ser42) Polyclonal

Specificity：This antibody detects endogenous levels of PAR1 (Cleaved-Ser42).

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000, ELISA 1:10000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)

Observed Band(KD)：46kD

Background： Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],

Function：function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Platelets and vascular endothelial cells.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Platelets and vascular endothelial cells.