Target:PDE4C
Fields:Purine metabolism;Metabolic pathways;cAMP signaling pathway;Parathyroid hormone synthesis, secretion and action;Morphine addiction
Gene Name:PDE4C
Protein Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Human Gene Id:5143
Human Swiss Prot No:Q08493
Mouse Gene Id:110385
Mouse Swiss Prot No:Q3UEI1
Rat Swiss Prot No:P14644
Immunogen:The antiserum was produced against synthesized peptide derived from human PDE4C. AA range:291-340
Specificity:PDE4C Polyclonal Antibody detects endogenous levels of PDE4C protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:PDE4C;DPDE1;cAMP-specific 3';5'-cyclic phosphodiesterase 4C;DPDE1;PDE21
Observed Band(KD):80kD
Background: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],
Function:catalytic activity:Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.,enzyme regulation:Inhibited by rolipram.,pathway:Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,tissue specificity:Expressed in various tissues but not in cells of the immune system.,
Subcellular Location:Cell projection, cilium .
Expression:Expressed in various tissues but not in cells of the immune system.