Target:PDE1A
Fields:Purine metabolism;Metabolic pathways;Calcium signaling pathway;Olfactory transduction;Taste transduction;Renin secretion;Morphine addiction
Gene Name:PDE1A
Protein Name:Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1)
Human Gene Id:5136
Human Swiss Prot No:P54750
Mouse Swiss Prot No:Q61481
Immunogen:Synthesized peptide derived from part region of human protein
Specificity:PDE1A Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):58kD
Background: Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009],
Function:catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,enzyme regulation:Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).,function:Has a higher affinity for cGMP than for cAMP.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,subunit:Homodimer.,tissue specificity:Several tissues, including brain, kidney, testes and heart.,
Subcellular Location:nucleus,cytosol,neuronal cell body,
Expression:Several tissues, including brain, kidney, testes and heart.