Target：PENK

Fields：Neuroactive ligand-receptor interaction

Gene Name：PENK

Protein Name：proenkephalin

Human Gene Id：5179

Human Swiss Prot No：P01210

Mouse Gene Id：18619

Mouse Swiss Prot No：P22005

Immunogen：Synthetic peptide from human protein at AA range: 51-100

Specificity：The antibody detects endogenous PENK protein

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PENK

Observed Band(KD)：33kD

Background： This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015],

Function：function:Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.,PTM:The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.,similarity:Belongs to the opioid neuropeptide precursor family.,

Subcellular Location：Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen . Secreted .

Expression： Brain,Cerebellum,Testis,