Target：PDZK3
Gene Name：PDZD2
Protein Name：PDZ domain-containing protein 2
Human Gene Id：23037
Human Swiss Prot No：O15018
Rat Gene Id：65034
Rat Swiss Prot No：Q9QZR8
Immunogen：The antiserum was produced against synthesized peptide derived from human PDZD2. AA range:51-100
Specificity：PDZK3 Polyclonal Antibody detects endogenous levels of PDZK3 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：PDZD2;AIPC;KIAA0300;PDZK3;PDZ domain-containing protein 2;Activated in prostate cancer protein;PDZ domain-containing protein 3
Molecular Weight(Da)：302kD
Background： The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015],
Function：disease:May be associated with the early promotion of prostate tumoregenesis.,PTM:A secreted form is produced by caspase-mediated proteolytic cleavage.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 6 PDZ (DHR) domains.,subcellular location:At cell-cell contacts in lung epithelial cells.,subunit:Interacts with SCN10A, CTNND2 and PKP4.,tissue specificity:Expressed (at protein level) in prostate and many prostate tumors.,
Subcellular Location：Nucleus . Cytoplasm . Endoplasmic reticulum . At cell-cell contacts in lung epithelial cells. .; [Processed PDZ domain-containing protein 2]: Secreted .
Expression：Isoform 2 is expressed (at protein level) in prostate and many prostate tumors.
