Target:PDS5B
Gene Name:PDS5B APRIN AS3 KIAA0979
Protein Name:Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3)
Human Gene Id:23047
Human Swiss Prot No:Q9NTI5
Mouse Swiss Prot No:Q4VA53
Rat Swiss Prot No:Q6TRW4
Immunogen:Synthesized peptide derived from human protein . at AA range: 90-170
Specificity:PDS5B Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):159kD
Background:PDS5 cohesin associated factor B(PDS5B) Homo sapiens This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015],
Function:disease:Defects in PDS5B may be the cause of some cancers including esophageal cancer.,function:Plays a role in androgen-induced proliferative arrest in prostate cells. Required for maintenance of sister chromatid cohesion during mitosis.,induction:By the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Maximum levels occur 18-20 hours after androgen exposure.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the PDS5 family.,similarity:Contains 1 HEAT repeat.,similarity:Contains 3 A.T hook DNA-binding domains.,subunit:Interacts with the cohesin complex.,tissue specificity:Widely expressed.,
Subcellular Location:Nucleus .
Expression:Widely expressed.